yabo88登陆

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科研进展

2020年11月19日
yabo88登陆在金黄色葡萄球菌胞内-胞外信息传递机制研究方面取得突破

yabo88登陆2020nian11yue16ri,yabo88dengluweichiduwuzhikexueguojiayanjiuzhongxin、shengmingkexuexueyuantaoyuyongjiaoshou、lixufujiaoshoutuanduizaimeiguokexueyuanyuankan《pnas》zaixianfabiaotiwei“interface switch mediates signal transmission in a two-component system”deyanjiulunwen,zongheyunyongshengwuhuaxuehejiegoushengwuxueyanjiushouduan,jieshilebaowaig6pxinhaotongguojinhuangseputaoqiujunhptrsachuanganqifuhewushixianbaonei-baowaixinhaozhuandaodejiegoujizhi。

weileshiyingbuduanbianhuadehuanjing,xijunbixuxunsudijiangxibaowaixinxizhuanhuaweishidangdexibaoneibufanying。shuangzufenxitong(tcs)shiyuanhexibaojianghuanjingcijizhuanhuaweixibaofanyingdezhuyaoxinhaozhuandaodanbai,tatongchangyoumobaomaizuansuanjimeihebaozhifanyingdiaojieqizucheng。hptrsashiyizhongxinjinfaxiandetcs,youg6pxiangguanchuanganqidanbai(hpta)、kuamozuansuanjimei(hpts)hexibaozhixiaoyingqi(hptr)zucheng。hptrsajiedaoputaotang-6-linsuan(g6p)shequ,zhichijinhuangseputaoqiujunzaibutongsuzhuxibaoneideshengzhanghezengzhi,danhptrsachuanganqifuhewuganzhig6pxinhaobingchufaxiayoufanyingdefenzijizhiyizhiyilaidouhaishigemi。

图1:HptA-HptS信号转导系统结合G6P信号前后的结构变化

yabo88登陆taoyuyong/lixutuanduitongguofenbiejiexiwudiwuzhuangtaiheg6pjiehezhuangtaidehptajiegou,faxiang6pkeyijieheyulianggehptadanbaijiandefengxizhong,bingnengyinqilianggehptadanbaixianghukaolong。hptadanbaiyuhptsdanbaixibaozhouzhijiegouyu(hptsp)defuhewujiegouxianshi,hptakeyitongguozuchengxingjiemianyijilingyigekeqiehuanjiemianyuhptsjinxingbutongxingshidexianghuzuoyong:bujieheg6pdeshihou,hptahehptspyuanlimodeyicejiehe,bingdaozhilianggehptspyixianghupingxingdefangshipailie;danghptajieheleg6pyihou,hptayuhptspdejieheweidianqiehuanzhikaojinmodeyice,yinfahptspxuanzhuan,bingshilianggehptspdecmoduanxianghukaojin,jineryinfabaowaixinhaoxiangbaoneizhuandao。zaishangshujiegoufaxiandejichushang,taoyuyong/lixutuanduijieheduihptahehptstubiantideshenghuaheshengzhangfenxi,tichulejiemiankaiguanjiedaodeg6p-hptrsaxinhaozhuandaojizhi。shangshuyanjiujieguoweixijundeyingyangganyingjizhitigonglezhongyaoxiansuo,kuozhanlexuejieduitcschuandiwaibuxinhaodejihuomoshidelijie。

图2:HptA-HptS信号转导系统的可能激活机制

yabo88登陆wangmingxingboshiheguoqiongboshiweigailunwendediyizuozhe,taoyuyongjiaoshou、lixufujiaoshouweilunwentongxunzuozhe。gaiyanjiushouguojiazirankexuejijinweimianshangxiangmu、lianhejijinxiangmuheguojiazhongdianyanfajihuazizhu。

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